ارتباط مارکرهای پیش‌التهابی با پراکسیداسیون لیپیدی متعاقب تمرین منظم در آب و مکمل‌گیری زنجبیل در مبتلایان به سرطان پستان

 Background and Objective: Recent studies have demonstrated the obese–induced oxidative stress and inflammation are risk factors for breast cancer. The aim of this study was to determine the relationship of the pro-inflammatory markers, lipid peroxidation and body fat percentage after 6 weeks of regular water-based exercise and ginger supplement in obese women with breast cancer.  Materials and Methods: In a semi-experimental study, forty obese women diagnosed with breast cancer with weight 76±9 kg and fat mass of 41.8±4 percent were randomly divided into four groups: placebo, water-based exercise, ginger supplement and a combined group of water-based exercise and ginger supplement. Subjects of the ginger supplement and combined group were receiving 4 capsules of ginger powder on a daily basis (each capsule contained 750 mg), for 6 weeks. The water-based exercise training program was collected at a progressive intensity and time: 4 times a week for 6 weeks.     Results: Implementation of water-based exercise, ginger supplement and the combined programs caused a significant decrease in concentration of interleukin -6 (IL-6) and C-reactive protein (CRP), malondialdehyde (MDA) and fat mass. However, considering Pearson correlation coefficient, it was concluded that just the relationship between fat mass and MDA in the ginger supplement group was significant (r= 0.63, p= 0.05).   Conclusion: Although performing water-based exercise and ginger supplement programs attenuate systemic inflammation and oxidative stress in obese women with breast cancer, there was no relationship between stress and changes of pro-inflammatory markers.